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Liposome drug delivery system has been extensively studied among many different nano-preparations

If the accumulation of hydrogen peroxide is not limited, it can diffuse to the cytosol or participate in a chain of reactions that generate more reactive free radicals, such as hydroxyl radical, which can oxidize mitochondrial components (proteins, lipids, and DNA)

This is the practical reason a reader who is nervous about small-volume accuracy might prefer the 50 mg protocol the trade-off being that each vial carries fewer total doses, as the supply math shows next